Published on
November 26, 2024

News

Could antigen modulation address autoimmune diseases?

Our CEO & Co-founder, Pete Joyce, speaks with Labiotech on their Beyond Biotech podcast about our origins, clinical progress, and the potential of our approach in developing treatments for autoimmune diseases.

Listen now 🎙️

01:19-04:12: About Greywolf Therapeutics
04:12-04:51: The origins of the name
04:51-06:52: The three ‘signals’ of the mechanics of immunological responses
06:52-08:31: Treatments associated with each signal
08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments?
10:09-11:28: What areas of disease is this applicable to?
11:28-12:19: How do you inhibit ERAP?
12:19-14:01: Greywolf Therapeutics’ candidates
14:01-15:11: How is this an advance on current treatments?
15:11-16:05: What is success for patients?
16:05-17:20: How does the stage of disease affect treatment?
17:20-18:09: Are other companies looking into antigen modulation?
18:09-19:47: Has this led to investment opportunities?
19:47-21:15: Next steps
21:15-21:55: Do you anticipate more interest in this space?
21:55-23:21: Attending events

About Greywolf Therapeutics

Greywolf Therapeutics is a clinical-stage biotech company advancing novel antigen modulation technology that controls T cells to guide the immune system. Our technology modulates antigen presentation, flicking a switch inside cells to alter their appearance to the immune system. We are progressing first-in-class antigen modulators to treat people living with cancers,  autoimmune disorders, and infectious diseases.

Our lead antigen modulator (GRWD5769) delivered strong results during a phase I/II trial in oncology, demonstrating proof-of-mechanism and target engagement, while our second (GRWD0715) is accelerating through preclinical development as a potential treatment within autoimmunity.

Greywolf is headquartered in Oxford, UK.

More information: Website | LinkedIn

Media enquiries

Patrick White, Head of Communications

+44 (0)1235 644 970

patrick.white@gwt.bio

Discover how our therapies are reshaping treatment for various diseases and conditions.

Harnessing antigen modulation to empower T cells against diseases.